Isozyme pattern of leukocyte α-d-mannosidase in patients with mannosidosis
نویسندگان
چکیده
منابع مشابه
Lysosomal alpha-mannosidase and alpha-mannosidosis.
Lysosomal alpha-mannosidase with acidic pH optimum is ubiquitous in human tissues where is expressed in two major forms, A and B that are the product of a single gene located on chromosome 19. Mutations in the gene encoding for alpha-mannosidase cause alpha- mannosidosis, an autosomal recessive disease, resulting in the accumulation of unprocessed mannose containing oligosaccharide material. Th...
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Lysosomal α-D-mannosidase is an exoglycosidase involved in the ordered degradation of N-linked oligosaccharides. It is ubiquitously expressed, although the main transcript is more abundant in peripheral blood leucocytes. Here we report that α-D-mannosidase enzyme activity is very high in the promyelocytic leukaemia cell lines HL60 and NB4, as compared with other leukaemic cell lines or cells fr...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: Japanese journal of human genetics
سال: 1988
ISSN: 0021-5074
DOI: 10.1007/bf01891236